Is adalimumab protective in ischemia-reperfusion injury in lung?


Kurt A., TUMKAYA L. , Kalkan Y., TÜRÜT H. , CURE M. C. , CURE E., ...More

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.18, no.11, pp.1093-1099, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 11
  • Publication Date: 2015
  • Title of Journal : IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Page Numbers: pp.1093-1099

Abstract

Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I-R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor-alpha (TNF-alpha) inhibitor agent. We aimed to evaluate whether Ada would prevent the lung tissue from damage development over the I-R process.