IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.18, no.11, pp.1093-1099, 2015 (Journal Indexed in SCI)
Article / Article
Title of Journal :
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
Adalimumab, Endothelin-1, Ischemia reperfusion, Lung injury, Tumor necrosis factor-alpha, RHEUMATOID-ARTHRITIS, ENDOTHELIN-1, MALONDIALDEHYDE, INFLIXIMAB, APOPTOSIS, SAFETY
Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I-R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor-alpha (TNF-alpha) inhibitor agent. We aimed to evaluate whether Ada would prevent the lung tissue from damage development over the I-R process.