The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells

Kalkan Y., BOSTAN H., TÜMKAYA L., TOMAK Y., Bostan M., YILMAZ A., ...More

JOURNAL OF ANESTHESIA, vol.26, no.6, pp.870-877, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1007/s00540-012-1440-4
  • Journal Name: JOURNAL OF ANESTHESIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.870-877
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Rocuronium has been associated with muscle weakness when administered in prolonged infusions. The effect of sugammadex and rocuronium together on muscle is unknown. In this study, we examined the effects of rocuronium and sugammadex, and the complex formed by these agents, on cardiac and diaphragmatic muscle cells.