Effects of iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model


EMRECAN B., TULUKOGLU E., Bozok S. , KESTELLI M., ONEM G., Kuepelioglu A., ...Daha Fazla

EUROPEAN JOURNAL OF MEDICAL RESEARCH, cilt.11, ss.295-299, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 7
  • Basım Tarihi: 2006
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • Sayfa Sayıları: ss.295-299

Özet

Objective: In ischemia-reperfusion, Iloprost decreases neutrophil activation and aggregation besides inhibition of oxygen-free radical production. Pentoxifylline (Ptx) attenuates reperfusion-associated membrane injury and tissue edema, suppresses leukocyte adhesion and improves hindlimb blood flow during the reperfusion period. The primary hypothesis in this study was that Iloprost could present better protection than pentoxyfillin on renal ischemia-reperfusion in rabbit model.