Effects of iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model

EMRECAN B., TULUKOGLU E., Bozok S., KESTELLI M., ONEM G., Kuepelioglu A., ...More

EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol.11, no.7, pp.295-299, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 7
  • Publication Date: 2006
  • Journal Name: EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.295-299
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Objective: In ischemia-reperfusion, Iloprost decreases neutrophil activation and aggregation besides inhibition of oxygen-free radical production. Pentoxifylline (Ptx) attenuates reperfusion-associated membrane injury and tissue edema, suppresses leukocyte adhesion and improves hindlimb blood flow during the reperfusion period. The primary hypothesis in this study was that Iloprost could present better protection than pentoxyfillin on renal ischemia-reperfusion in rabbit model.