Effects of iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model


EMRECAN B., TULUKOGLU E., Bozok S. , KESTELLI M., ONEM G., Kuepelioglu A., ...More

EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol.11, no.7, pp.295-299, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 7
  • Publication Date: 2006
  • Title of Journal : EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • Page Numbers: pp.295-299

Abstract

Objective: In ischemia-reperfusion, Iloprost decreases neutrophil activation and aggregation besides inhibition of oxygen-free radical production. Pentoxifylline (Ptx) attenuates reperfusion-associated membrane injury and tissue edema, suppresses leukocyte adhesion and improves hindlimb blood flow during the reperfusion period. The primary hypothesis in this study was that Iloprost could present better protection than pentoxyfillin on renal ischemia-reperfusion in rabbit model.