Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis


YILMAZ Y., Kedrah A. E. , Ozdogan O.

WORLD JOURNAL OF GASTROENTEROLOGY, vol.15, no.35, pp.4387-4391, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 15 Issue: 35
  • Publication Date: 2009
  • Doi Number: 10.3748/wjg.15.4387
  • Journal Name: WORLD JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.4387-4391

Abstract

Nonalcoholic fatty liver disease (NAFLD) remains a leading cause of chronic liver disease. In the context of NAFLD, the presence of nonalcoholic steatohepatitis (NASH) portends an adverse prognosis with greater risk of liver fibrosis and cirrhosis. Although liver biopsy is the keystone of patient management in NAFLD, it is also increasingly clear that such evaluation has its limitations. The availability of biochemical markers of NAFLD and NASH has tremendous potential to radically alter management strategies for these conditions, as well as to monitor disease activity. Our article provides an overview of biomarker discovery and selection in the setting of NAFLD and highlights future directions in the field. (C) 2009 The WJG Press and Baishideng. All rights reserved.