Synthesis and antioxidant, antiurease and anti-xanthine oxidase activities of some new benzimidazoles bearing triazole, oxadiazole, thiadiazole and imin function

Karaali N., Baltas N., Mentese E.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol.57, no.3, pp.374-384, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 3
  • Publication Date: 2018
  • Journal Name: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.374-384
  • Keywords: Benzimidazole, antioxidant, antiurease, anti-xanthine oxidase, ANTIVIRAL ACTIVITY, DERIVATIVES, INHIBITORS, RINGS, RAT
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

In this study, a series of new 2-(4-nitrobenzyl)-1H-benzimidazole derivatives bearing thiosemicarbazide, triazole, oxadiazole and thiadiazole moieties at the 1st position of benzimidazole ring have been synthesized and screened for their antioxidant, antiurease and anti-xanthine oxidase activities. Antioxidant activities of the synthesized compounds have been determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds show significant antioxidant activity. Also, among the tested compounds, 9c displays the best inhibitory effect against XO with an IC50 value of 12.30 +/- 0.33 mu g/mL and compound 7ashows the best inhibitory effect against urease with an IC50 value of 13.04 +/- 0.89 mu g/mL.