Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9

Yilmaz B., Sucak A., Kilic S., Aksakal O., BAYAZIT Y., Lortlar N., ...More

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol.202, no.4, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 202 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1016/j.ajog.2009.10.873
  • Journal Name: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: endometriosis, malondialdehyde, matrix metalloproteinase-9, metformin, rat, superoxide dismutase, tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, TYPE-2 DIABETIC-PATIENTS, MATRIX METALLOPROTEINASES, EUTOPIC ENDOMETRIUM, ESTROGEN-RECEPTOR, NUDE-MICE, EXPRESSION, MODEL, EXPLANTS, PERITONEAL, VEGF
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

OBJECTIVE: We sought to test if metformin could regress endometriotic explants in rats.