A rare localization of a common disease: Primary uterine Non-Hodgkin lymphoma mimicking leiomyosarcoma

GÖKSEL S., Karaman E., Karacin P., ERSÖZ Ş.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.18, no.4, pp.1205-1207, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.4103/jcrt.jcrt_435_22
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1205-1207
  • Keywords: Extra-nodal lymphoma, FDG PET/CT, post-menopausal bleeding, uterus, EXTRANODAL INVOLVEMENT, PET/CT
  • Recep Tayyip Erdoğan University Affiliated: Yes


Genitourinary system lymphomas comprise a small part of extra-nodal lymphomas (ENLs). ENLs of uterine origin are extremely rare and are often confused with gynecological malignancies. We present an 80-year-old female patient diagnosed with diffuse large B-cell lymphoma (DLBCL) with a single focus of the uterus. The patient's only complaint was abnormal uterine bleeding. Magnetic resonance imaging revealed an intramural-subserous-submucous multiple mass lesion with minimal contrast enhancement mimicking leiomyosarcoma. Diffuse pathological 18F-fluorodeoxyglucose uptake was detected in the entire uterus corpus and cervix on positron emission tomography/computed tomography (PET/CT) scanning. The pathology of the endocervical and endometrial curettage material obtained was DLBCL; the patient was diagnosed with ENL, and a single focus was the uterus. ENLs should be considered in the differential diagnosis of gynecological malignancies in patients with abnormal uterine bleeding. PET/CT is crucial in showing metabolically active spread areas in these patients.