Protective Effect of Tea Grape Extract on Cisplatin-Induced Muscle Atrophy: A Morphological Study


BALIK M. S. , TUMKAYA L. , MERCANTEPE T. , YILMAZ A. , BALIK G. , TOPCU A. , ...More

IRANIAN RED CRESCENT MEDICAL JOURNAL, vol.20, no.9, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 9
  • Publication Date: 2018
  • Doi Number: 10.5812/ircmj.66319
  • Title of Journal : IRANIAN RED CRESCENT MEDICAL JOURNAL

Abstract

Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. In skeletal muscles, the toxic effect manifests as atrophy. 

Objectives: The tea grape extract (TGE) is a sort of whortleberry that has various physiological effects including prevention of chemically induced cellular insults. Therefore, we examined if the TGE has a protective effect against the Cis induced skeletal muscle atrophy. 

Methods: Female Sprague-Dawley rats were used in this animal experimental study. Rats were allocated into different study groups, each with eight members. The groups comprised control, solvent control, 200 mg TGE, Cis, Cis + 100 mg TGE, and Cis + 200 mg TGE. 

Results: The mean fiber area of the skeletal muscle (MFASM) decreased significantly in the Cis group in comparison to the control group (P = 0.01). MFASM showed similarities between the Cis + TGE 200 and control groups (P > 0.05, P = 0.418). Similarities were also observed for MFASM between the Cis + 100 mg TGE and Cis + 200 mg TGE groups (P > 0.05, P = 0.891). The mean serum calcium level in the Cis group (10.26 +/- 0.29) was significantly higher in TGE 100 (9.13 +/- 0.11) and TGE 200 groups (9.21 +/- 0.13). 

Conclusions: It is concluded that the tea grape extract has a protective effect on Cis-induced toxicity of the skeletal muscles.

Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. In skeletal muscles, the toxic effect manifests as atrophy.