Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype

Yilmaz B., Gungor T., Bayramoglu H., Soysal S., Mollamahmutoglu L.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, cilt.36, sa.3, ss.697-700, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1111/j.1447-0756.2010.01225.x
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.697-700
  • Anahtar Kelimeler: adolescent, coexisting, dysgerminoma, gonadoblastoma, PHENOTYPIC FEMALE, WOMAN
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Gonadoblastoma is a rare gonadal tumor with tumor cells arranged in nests surrounded by ovarian stroma containing Leydig or lutein-type cells. In 50% of the cases, there is an overgrowth of germ cells with progression to dysgerminoma. A case of gonadoblastoma with coexisting dysgerminoma developing in both ovaries of a 20-year-old girl who had increased abdominal girth is presented here. A pelvic mass measuring 20 x 14 cm was detected by pelvic ultrasonography. Bilateral salphingo-oophorectomy was performed. The histopathological report revealed bilateral gonadoblastoma with coexisting dysgerminoma. After surgery the patient received radiation and chemotherapy (BEP: bleomycin, etoposide, cisplatin) and was started on hormone replacement therapy. Five years and eight months after treatment, the patient is well and free of recurrence.