Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype


Yilmaz B., Gungor T., Bayramoglu H., Soysal S., Mollamahmutoglu L.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, vol.36, no.3, pp.697-700, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1111/j.1447-0756.2010.01225.x
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.697-700
  • Keywords: adolescent, coexisting, dysgerminoma, gonadoblastoma, PHENOTYPIC FEMALE, WOMAN
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Gonadoblastoma is a rare gonadal tumor with tumor cells arranged in nests surrounded by ovarian stroma containing Leydig or lutein-type cells. In 50% of the cases, there is an overgrowth of germ cells with progression to dysgerminoma. A case of gonadoblastoma with coexisting dysgerminoma developing in both ovaries of a 20-year-old girl who had increased abdominal girth is presented here. A pelvic mass measuring 20 x 14 cm was detected by pelvic ultrasonography. Bilateral salphingo-oophorectomy was performed. The histopathological report revealed bilateral gonadoblastoma with coexisting dysgerminoma. After surgery the patient received radiation and chemotherapy (BEP: bleomycin, etoposide, cisplatin) and was started on hormone replacement therapy. Five years and eight months after treatment, the patient is well and free of recurrence.