The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

Kurt A., Tumkaya L., Yuce S., Turut H., Cure M. C., Sehitoglu I., ...More

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.19, no.6, pp.685-691, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2016
  • Journal Name: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.685-691
  • Keywords: Carbon tetrachloride, Infliximab, Nitric oxide, Pulmonary toxicity, Oxidative stress, CCL4-INDUCED OXIDATIVE STRESS, INDUCED LIVER-INJURY, RHIZOME EXTRACT, RATS, TOXICITY, ALPHA, AMELIORATION, FIBROSIS, DAMAGES, KIDNEY
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury.