Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats

BAHÇECİ İ., TÜMKAYA L., MERCANTEPE T., YILMAZ H., Ibik Y. E., DURAN Ö. F., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.27, sa.3, ss.1140-1146, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.26355/eurrev_202302_31220
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1140-1146
  • Anahtar Kelimeler: Carbon tetrachloride, CD3, CD68, CD200R, Spleen, LIVER, METHOTREXATE, APOPTOSIS, INJURY
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Carbon tetrachlo-ride (CCl4) is a non-polar molecule used in indus-try in grain curing, insect-killing and especially in the production of chlorofluorocarbons. It is esti-mated that an average of 70,000 industry workers in Europe are exposed to this toxic compound.MATERIALS AND METHODS: Twenty-four male Sprague-Dawley rats were randomly allo-cated into four groups: control group (saline on-ly, Group I), infliximab (INF) group (Group II), CCl4 group (Group III) and CCl4+INF group (Group IV).RESULTS: While there was an increase in the numerical density of CD3, CD68, and CD200R positive T lymphocytes and macrophages in the CCl4 administration group (p=0.000), this was not the case in the CCl4+INF administration group (p=0.000).CONCLUSIONS: TNF-alpha inhibitors have a pro-tective effect against CCl4-induced spleen tox-icity/inflammation as seen by the reduction in CD3, CD68, CD200R positive T lymphocytes and macrophages.