Epicardial Adipose Tissue is Associated with Increased Systolic Pulmonary Artery Pressure in Patients with Chronic Obstructive Pulmonary.

Kalaycıoğlu E., Çetin M. , Çinier G., Özyıldız A., Durmuş İ., Kırış T., ...More

The clinical respiratory journal, vol.15, pp.406-412, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2021
  • Doi Number: 10.1111/crj.13316
  • Title of Journal : The clinical respiratory journal
  • Page Numbers: pp.406-412
  • Keywords: chronic obstructive pulmonary disease, epicardial adipose tissue, pulmonary hypertension, systolic pulmonary arterial pressure, XANTHINE-OXIDASE, ENDOTHELIAL DYSFUNCTION, COPD, HYPERTENSION, FAT, STANDARDS, DIAGNOSIS


Objectives Pulmonary hypertension (PHT) is one of the essential predictors of mortality in chronic obstructive pulmonary disease (COPD). It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation, and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role as a metabolically active endocrine organ and secretes various proinflammatory cytokines. We hypothesized that EAT thickness in COPD patients might be associated with the systolic pulmonary arterial pressure (PAPs) level, and we aimed to test it.