Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholin


DEMİRCİ S., Aksakal F., ÇOLAK N., Ulker S., DEMİRBAŞ A., DEMİRBAŞ N.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.4, pp.444-463, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.2174/1570180813666161024165613
  • Title of Journal : LETTERS IN DRUG DESIGN & DISCOVERY
  • Page Numbers: pp.444-463

Abstract

Background: The amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave techniques. The synthesis of 1,3,4-oxadiazole (8), arylidenenhydrazide (9a-c) and carbothioamides (10a,b) was performed with the treatment of 7 with CS2, suitable amines and suitable isothiocyanates, respectively.