Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholin

DEMİRCİ, SERPİL; Aksakal, Fatma; ÇOLAK, NESRİN; Ulker, SERDAR; DEMİRBAŞ, AHMET; DEMİRBAŞ, NESLİHAN

doi:10.2174/1570180813666161024165613

Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholin

Copy For Citation

DEMİRCİ S., Aksakal F., ÇOLAK N., Ulker S., DEMİRBAŞ A., DEMİRBAŞ N.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.4, pp.444-463, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 14 Issue: 4
Publication Date: 2017
Doi Number: 10.2174/1570180813666161024165613
Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.444-463
Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: The amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave techniques. The synthesis of 1,3,4-oxadiazole (8), arylidenenhydrazide (9a-c) and carbothioamides (10a,b) was performed with the treatment of 7 with CS2, suitable amines and suitable isothiocyanates, respectively.