Understanding the flow process of cemented tailings backfill (CTB) is important for successful pumping into underground stopes. This study examines the effects of solid content (SC), cement/tailings (c/t) ratio, and curing time (CT) on rheological and mechanical properties of CTB mixes. The slurry concentration of the mixes was 65, 67, and 69 wt. %, with c/t ratios ranging from 1:4 to 1:20. Unconfined compressive strength (UCS) tests were performed on hardened CTB mixes after curing 3, 7, and 28 days. The rheological properties of CTB slurries are mainly related to SC. The yield stress and viscosity of fresh mixes increase with increasing SC, but the pipeline resistance loss (PRL) also increases with increasing SC. According to the analysis of variance, the SC and flow rate are the most significant parameters which greatly affect the PRL performance. The c/t and CT parameters are the most significant parameters for affecting the shrinkage rate. The findings offer a reference for theoretical optimization for mine filling systems of similar type.