Present study consists the spatial and temporal distributions of some pollutants resulting from marine and terrestrial activities were studied from the water column of the southeastern Black Sea between November 2009 and October 2010. Observed concentrations of phenol (max. 14.21 mu g/l), anionic detergent (max. 28.80 mu g/l), oil and grease (max. 102.90 mg/l), turbidity (max 20.20) and total suspended solids (max. 18.72 mg/l) in Black Sea water samples indicated irregular seasonal and spatial distributions. Some of the toxic pollutants exceeded the marine water quality criteria of Turkish Water Pollution and Control Regulation, suggesting significant impact of marine and terrestrial activities on the coastal waters of southeastern Black Sea. In sum, the levels of pollutants measured in this study decrease from nearshore to offshore, and the data show low variability with respect to depth. Accordingly, it can be said that the study areas are significantly affected by anthropogenic additions from wastewater discharge.