Research Information System
Indian Journal of Chemistry (IJC), vol.62, no.7, pp.728-734, 2023 (Scopus)
Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their α-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of FT-IR, 1H and 13C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and 2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been evaluated for their in vitro inhibitory activity against α-glucosidase and all of them have more inhibitory effect when compared to acarbose as reference compound. Especially, compound 2 shows the most significant α-glucosidase inhibition. IC50 values of compound 2 and acarbose, which is known as α-glucosidase inhibitor used as anti-diabetic drug, have been found to be 6.01±0.16 and 9.52±0.23 µg/mL, respectively.