Epidemiology, natural history, and diagnosis of metabolic dysfunction-associated fatty liver disease: a comparative review with nonalcoholic fatty liver disease

Kaya E., Yılmaz Y.

THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM, cilt.13, ss.1-13, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1177/20420188221139650
  • Dergi Adı: THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1-13
  • Anahtar Kelimeler: diagnosis, epidemiology, fibrosis, metabolic (dysfunction)-associated fatty liver disease, nonalcoholic fatty liver disease, CONTROLLED ATTENUATION PARAMETER, NAFLD FIBROSIS SCORE, HEPATIC STEATOSIS, PRIMARY-CARE, OUTCOMES, INDEX, STEATOHEPATITIS, ELASTOGRAPHY, MANAGEMENT, MORTALITY
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide – with an estimated global prevalence of 37%. Different from nonalcoholic fatty liver disease (NAFLD), which is an exclusion diagnosis, MAFLD is defined by a set of positive criteria. This recent change in terminology is challenging because MAFLD and NAFLD denote two similar, albeit not identical, clinical populations. When the diagnostic criteria for MAFLD are applied, liver histology appears more severe and clinical outcomes are less favorable. However, the clinical management of MAFLD and NAFLD remains similar. While liver biopsy is still the reference standard for achieving a final diagnosis, noninvasive imaging- or biomarker-based diagnostic modalities are currently gaining momentum. However, liver biopsy should be recommended when diagnostic challenges exist. In this review, we compared the epidemiology, natural history, and diagnosis of MAFLD with respect to the traditional NAFLD definition.