The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Bedir R., Gucer H., Sehitoglu I., YURDAKUL C., Bagci P., USTUNER P.

BALKAN MEDICAL JOURNAL, vol.33, no.2, pp.121-127, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.5152/balkanmedj.2016.16442
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.121-127
  • Keywords: Differential diagnosis, immunohistochemistry, keratoacanthoma, skin, squamous cell carcinoma, MALIGNANT SKIN-LESIONS, DISTINGUISH KERATOACANTHOMAS, RECEPTOR EXPRESSION, PROLIFERATION, PROTEINS, BENIGN, TUMORS, CYCLE, INHIBITOR, APOPTOSIS
  • Recep Tayyip Erdoğan University Affiliated: Yes


Background: Distinguishing squamous cell carcinoma (SCC) from keratoacanthoma (KA) by histopathological features may not be sufficient for a differential diagnosis, as KAs may, in some cases, imitate well-differentiated SCCs.