Akademik Veri Yönetim Sistemi
Handbook of the Biology and Pathology of Mental Disorders, Springer International Publishing Ag, ss.2059-2077, 2025
Specific learning disorder (SLD) is a neurodevelopmental disorder characterized by difficulties experienced in reading, written expression, and arithmetic skills. Although its etiology has not been clearly determined yet, it is accepted that the interaction of genetic and environmental factors plays a role in its etiology. Identifying the main genetic factors that contribute to SLD is an important part of understanding the etiology. In addition, it is also important in terms of developing early intervention methods for this disorder, which is diagnosed during the school period, and making possible the applications related to the treatment. In genetic studies conducted on the etiology of SLD, many candidate genes have been proposed. One of these candidate genes is the forkhead box protein P2 (FOXP2) gene. This gene is the first gene identified in speech and language disorders. Speech-language disorder and the frequent comorbidity of SLD, especially the common etiology of reading disorders and speech-language disorders, have led to the investigation of this gene in SLD. In the studies conducted on this subject, strong evidence has been obtained regarding the role of the FOXP2 gene in the etiology of SLD. However, considering the cognitive characteristics of SLD, comorbid conditions, difficulties in defining the phenotype, and the varieties, it seems that more studies are needed in this area.