Serum YKL-40 levels as a novel marker of inflammation in patients with endometriosis


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URAL U. M. , Tekin Y. , CURE M., SAHIN F. K.

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, cilt.42, sa.4, ss.495-497, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.12891/ceog1882.2015
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
  • Sayfa Sayıları: ss.495-497

Özet

Purpose: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. Materials and Methods: This was a cross-sectional clinical study conducted in a tertiary care center. Demographics and serum YKL levels were determined and noted in a total of 63 cases (33 endometriosis patients, 30 healthy controls). Measurement of YKL-40 levels was made using a YKL-40 enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's protocol. Results: The mean serum YKL-40 levels of the patient group was 106.0 +/- 15.9 (range 23.44 to 382.55) years, while the mean serum YKL-40 levels of the controls was 52.2 +/- 7.0 (range 22.35 to 160.0) years (p = 0.003). Conclusions: This is the first study evaluating serum YKL-40 levels in endometriosis. The present results indicate that YKL-40 levels were increased in patients with endometriosis compared to controls. The authors propose that circulating YKL-40 levels could be a novel biomarker for diagnosis and follow-up of endometriosis.

Serum YKL-40 levels as a novel marker of inflammation in patients with endometriosis

By:Ural, UM (Ural, U. Mete)1 ] Tekin, YB (Tekin, Y. Bayoglu)1 ] Cure, M (Cure, M.)2 ] Sahin, FK (Sahin, F. Kir)1 ]

 

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY

 

Volume: 42

 

Issue: 4

 

Pages: 495-497

Published: 2015

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Abstract

Purpose: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. Materials and Methods: This was a cross-sectional clinical study conducted in a tertiary care center. Demographics and serum YKL levels were determined and noted in a total of 63 cases (33 endometriosis patients, 30 healthy controls). Measurement of YKL-40 levels was made using a YKL-40 enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's protocol. Results: The mean serum YKL-40 levels of the patient group was 106.0 +/- 15.9 (range 23.44 to 382.55) years, while the mean serum YKL-40 levels of the controls was 52.2 +/- 7.0 (range 22.35 to 160.0) years (p = 0.003). Conclusions: This is the first study evaluating serum YKL-40 levels in endometriosis. The present results indicate that YKL-40 levels were increased in patients with endometriosis compared to controls. The authors propose that circulating YKL-40 levels could be a novel biomarker for diagnosis and follow-up of endometriosis.

Keywords

Author Keywords:EndometriosisSerumYKL-40 levelsMarker

KeyWords Plus:ENDOTHELIAL GROWTH-FACTORMACROPHAGE DIFFERENTIATIONOVARIAN-CANCERANGIOGENESISGENECHI3L1WOMEN

Author Information

Reprint Address: Ural, UM (reprint author)

Recep Tayyip Erdogan Univ, Fac Med, Dept Obstet & Gynecol, Islampasa Mahallesi,Sehitler Caddesi 74, Rize, Turkey.

 

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