Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4)

Karakus E., Karadeniz A., Simsek N., Can I., Kara A., Yildirim S., ...More

JOURNAL OF HAZARDOUS MATERIALS, vol.195, pp.208-213, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 195
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jhazmat.2011.08.027
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.208-213
  • Recep Tayyip Erdoğan University Affiliated: Yes


The purpose of this study was to investigate possible beneficial effects of Panax ginseng (PG) on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in rats. CCl4 challenge elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the pretreatment of rats with PG. Histologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl4 group. Also, CD68(+) and caspase-3 staining cells were diffused in both lobular and portal areas. However, PG pretreatment had a little influence on the number of caspase-3 immunpositive staining cells in the liver, but CD68(+) staining areas were significantly decreased in the PG + CCl4 when compared to CCl4 group. We conclude that PG treatment may play a protective role by enhancing liver enzyme activities and recovering biochemical parameters, and improving the changes in histological structure against CCl4-induced liver damages in rats. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.