Research Information System
AICMES 9TH INTERNATIONAL CONFERENCE ON SCIENTIFIC STUDIES JAN 16 - 23, 2026 MECCA, Makkah, Saudi Arabia, 16 - 23 January 2026, pp.266, (Summary Text)
Microwave-assisted synthesis has emerged as an efficient and environmentally friendly approach in modern organic chemistry, offering advantages such as reduced reaction times, improved yields, and enhanced product purity compared to conventional heating methods. Isatin is a privileged heterocyclic scaffold widely found in biologically active molecules, while salicyl moieties are known for their antioxidant and pharmacological properties. Triazole rings play a crucial role in medicinal chemistry owing to their metabolic stability, strong hydrogen bonding capability, and broad spectrum of biological activities. Multicomponent reactions constitute an important part of synthetic organic chemistry due to their advantages such as short reaction times and high yields. These reactions have become frequently used methods in drug discovery studies, particularly because they allow the facile synthesis of biologically active organic molecules containing diverse functional groups. The combination of isatin, salicyl, and triazole units into a single hybrid framework is a rational strategy to enhance biological efficacy through synergistic effects. In this study, the synthesis of triazole-based hybrid compounds containing isatin and salicyl derivatives and the investigation of their antioxidant properties are aimed. Initially, nitrile compounds will be converted into the corresponding iminoester hydrochloride derivatives by treatment with ethanol and hydrogen chloride gas according to a literature method. Subsequently, the obtained iminoester compounds will be reacted with ethyl carbazate in ethanol to afford the corresponding hydrazone derivatives, following established literature procedures. In the next step, these hydrazones will be converted into amine derivatives through reaction with hydrazine hydrate. In the final stage, the resulting amine derivatives will be reacted with various isatin and salicyl derivatives to obtain different isatin- and salicyl-based compounds containing a triazole ring.