JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.11, no.1, pp.164-169, 2015 (SCI-Expanded)
Article / Article
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Arginase, carbamoyl phosphate synthetase 1, hepatotoxicity, infliximab, methotrexate, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE, CELL-GROWTH, INDUCED HEPATOTOXICITY, APOPTOSIS, THERAPY, CANCER
Recep Tayyip Erdoğan University Affiliated:
Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity.