Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction


Cure E., Kirbas A., TÜMKAYA L., Cure M. C., Kalkan Y., YILMAZ A., ...More

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.11, no.1, pp.164-169, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4103/0973-1482.140809
  • Journal Name: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.164-169
  • Keywords: Arginase, carbamoyl phosphate synthetase 1, hepatotoxicity, infliximab, methotrexate, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE, CELL-GROWTH, INDUCED HEPATOTOXICITY, APOPTOSIS, THERAPY, CANCER
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity.