Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction


Cure E., Kirbas A., TÜMKAYA L. , Cure M. C. , Kalkan Y., YILMAZ A., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.11, ss.164-169, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0973-1482.140809
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Sayfa Sayıları: ss.164-169

Özet

Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity.