Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction

Cure E., Kirbas A., TÜMKAYA L., Cure M. C., Kalkan Y., YILMAZ A., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.11, sa.1, ss.164-169, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0973-1482.140809
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.164-169
  • Anahtar Kelimeler: Arginase, carbamoyl phosphate synthetase 1, hepatotoxicity, infliximab, methotrexate, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE, CELL-GROWTH, INDUCED HEPATOTOXICITY, APOPTOSIS, THERAPY, CANCER
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity.