Effects of gadodiamide and gadoteric acid on lung tissue: A comparative study


Beyazal Çeliker F., Tümkaya L., Suzan Z. , Topcu A. , Mercantepe T. , Çinar S., ...More

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1002/jbt.23133
  • Title of Journal : JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Keywords: apoptosis, gadodiamide, gadoteric acid, lung, rat, GADOLINIUM, MALONDIALDEHYDE, EXPRESSION, DEPOSITION, TOXICITY, RATS

Abstract

We set out to investigate the effects of gadodiamide and gadoteric acid, used for magnetic resonance imaging, on the lungs. In this study, 32 male Sprague Dawley rats were used. These were allocated into four groups; The first group (control) was untreated. The second group received isotonic saline on the first and fourth days of the week for 5 weeks. Following the same schedule, the third and fourth groups received a total of 2 mg/kg gadodiamide and gadoteric acid, respectively, in place of saline. The alveolar Wall thickness was evaluated. Gadodiamide and gadoteric acid significantly increased the numbers of collagen-3 and caspase-3 positive cells in the lung tissue (p < 0.05). In addition, these two substances increased the alveolar Wall thickness (p < 0.05). Furthermore, they increased the levels of malondialdehyde and glutathione (p < 0.05). This study demonstrates that both linear and macrocyclic contrast agents are toxic for the lungs in rats.