The determination of molecular dynamic properties of Novel 5-oxo-1,2,4-triazole phthalocyanines and investigation of their urease inhibition properties

KAYA M., MENTEŞE E., Sokmen B. B., AKÇAY H. T.

JOURNAL OF MOLECULAR STRUCTURE, vol.1222, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1222
  • Publication Date: 2020
  • Doi Number: 10.1016/j.molstruc.2020.128870
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Keywords: Phthalocyanine, Fluorescence, Aggregation, Urease inhibition activity, SUBSTITUTED PHTHALOCYANINES, PHOTOCHEMICAL PROPERTIES, ZINC(II), DYES
  • Recep Tayyip Erdoğan University Affiliated: Yes


In present study, the novel peripherally [3-methyl 5 oxo 4 (4 phenoxyphenyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl] substituted Zn(II), Cu(II), Co(II) phthalocyanines were synthesized and characterized spectroscopically. The light absorption/emission behavior of the synthesized phthalocyanines were determined by UV-Vis and fluorescence spectroscopy. The fluorescence quantum yields of the novel phthalocyanine Zn(II) complex in different solvents were calculated. Besides, the urease inhibition activities of the novel compounds were investigated. All synthesized phthalocyanines have a superior inhibitory activity on urease enzyme, while novel phthalocyanines Cu(II) showed the best inhibitory effect against jack bean urease with IC(50 )values of 0.0035 +/- 0.0010 mu M. (C) 2020 Elsevier B.V. All rights reserved.