Aim: Healthcare workers are an occupational group that is at the forefront of a pandemic process, where morbidity and mortality are intense. Deaths due to COVID-19 among workers in our country and in the world are reported mostly in healthcare workers. In this study, we aimed to analyze the rate of contracting COVID-19 among healthcare workers after vaccination and the clinical features of the disease.Material and Methods: Between January 14, 2021 and June 29, 2021, the diagnosis of COVID-19 in healthcare workers who had clinical complaints after a single dose and two doses of vaccination was made as a result of the evaluation of the patients' throat and nose swab samples by reverse transcriptase-polymerase chain reaction (RT-PCR). The disease table of the positive patients was grouped as home treatment and hospital treatment by accessing clinical and laboratory records from electronic medical records.Results: At least one dose of vaccine was given to 11,540 (79.62%) of a total of 14,461 healthcare workers. COVID-19 positivity was detected in the PCR test performed on 51 single-dose vaccinated healthcare workers and 177 double-dose vaccinated healthcare workers with clinical complaints. While all patients vaccinated with a single dose were treated at home, 176 of the patients vaccinated with two doses were treated at home and 1 was treated in the hospital.Discussion: It has been seen that if countermeasures against COVID-19 are not taken, it could be a great disaster for the whole world, that the most important defense against this pandemic is vaccination, and that those who have COVID-19 after vaccination have a mild illness even if they have the disease.