Association Between Maternal Vitamin B12 Status and Risk of Gestational Diabetes Mellitus in Pregnant Women

GÜRLEK B., Karlı P.

V. Uluslararası Multidisipliner Çalışmaları Sempozyumu (ISMS), Ankara, Turkey, 16 - 17 November 2018, pp.768

  • Publication Type: Conference Paper / Summary Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.768
  • Recep Tayyip Erdoğan University Affiliated: Yes


Association Between Maternal Vitamin B12 Status and Risk of Gestational Diabetes Mellitus in Pregnant Women Asst. Prof. Ph.D. Beril Gürlek - Asst. Prof. Ph.D. Pervin Karlı ÖZ Aim: Research shows that serum vitamin B12 levels are reduced in diabetes including gestational diabetes. In present study, we sought to investigate whether maternal serum levels of vitamin B12 is associated with an increased risk of gestational diabetes mellitus (GDM). Methods: A retrospective case-control study of pregnant women attending the antenatal clinic in a University hospital in the Rize, Turkey, between 2017 and 2018 was conducted. Using the hospital information database which had routine materno-fetal records of all pregnancy during this period, we identified women who had a diagnosis of GDM and those who did not (labelled as no-GDM) and had their B12 levels measured in the first trimester of their pregnancies. The following women were excluded from our analysis: pre-gestational diabetes (Type 1 and 2), multiple pregnancies, and those on vitamin B12 supplements at the time of blood sampling. A universal screening approach was used to screen women for GDM according to The IADPSG International Association of the Diabetes and Pregnancy Study Groups criteria (IADPSGC) criteria. This consisted of a 2-h 75 g glucose tolerance test (GTT) between 24 and 28 weeks of gestation. The IADPSG criteria were used to diagnose GDM (fasting glucose ≥ 92 mg/dL or 1- h glucose ≥ 180 mg/dL 2-h glucose ≥ 153 mg/dL). Fifty-one women with GDM and 251 controls without GDM were included in this study. Results: The subjects were pregnant women aged 26.95±4.57 (mean±SD) years old. Their average gestational age was 26.53±4.06 weeks. Mean plasma vitamin B12 concentrations were not significantly different in women who subsequently developed GDM compared with those who did not (mean ± standard deviation: 241.56±97.481 pg/ml versus 213.51±70.052 pg/ml; p=0.232). Conclusion: Vitamin B12 status in early pregnancy is not significantly associated with elevated risk of GDM. Anahtar Kelimeler: Vitamin B12 Status, Gestational Diabetes Mellitus, Pregnancy