Alpha-lipoic acid prevents ethyl alcohol-induced apoptosıs and oxidatıve stress in kidneys

Uçmak F., Yıldızhan E.

Gaceta Médica de México, cilt.161, ss.1-9, 2025 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 161
  • Basım Tarihi: 2025
  • Doi Numarası: 10.24875/gmm.25000167
  • Dergi Adı: Gaceta Médica de México
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1-9
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Background:

Our aim was to investigate the therapeutic efficacy of Alpha-lipoic acid (ALA) against ethyl alcohol (EA)-induced oxidative stress and apoptotic pathways in the kidneys based on biochemical, histopathological, and apoptotic analysis.

Materials and methods:

Twenty-eight Wistar albino rats were randomly divided into four equal groups. Group I (Sham group): 1 cc saline daily; Group II (ALA): 100 mg/kg/dose/day; Group III (EA group): 5 g/kg/day; Group IV (EA + ALA group): both ALA and EA were administered orally with a gastric catheter simultaneously.

Results:

In the EA group, malondialdehyde and total oxidant status levels increased, while superoxide dismutase and catalase levels decreased significantly (p = 0.002). However, oxidant levels were significantly stabilized with ALA administration. Furthermore, apoptotic signals such as Bax and Apoptotic peptidase activating factor-1 were increased in the EA group, while Bcl-2 (antiapoptotic) signals were widely expressed with ALA administration.

Conclusions:

Co-administration of ALA with EA increased antiapoptotic expression and attenuated histologic damage in the kidneys. ALA may be a potential therapeutic agent against EA injury.

Keywords : Alpha-lipoic acid; Ethyl alcohol; Nephrotoxicity; Oxidative stress; Apoptosis.