It was aimed to determine the relationship between nurses' perceived social support levels and quality of life during the COVID-19 epidemic in the study. The study was conducted as a descriptive study in two provinces located in the northeast of Turkey between July and September 2021. The population of the study consisted of nurses working in two provinces during the pandemic process, and the sample consisted of 274 nurses who were reached by snowball sampling method and met the inclusion criteria of the study. In data collection; "Nurses' Descriptive Characteristics Form", "Perceived Multidimensional Social Support Scale" and "World Health Organization Quality of Life Scale" were used. The mean score of the perceived social support scale of the nurses was 65.84±14.32 and the mean score of the quality of life scale was 26.52±4.75. It was found that the quality of life of the nurses increased as the perceived social support scores increased (r=0.431, p<0.01). It was found that how nurses evaluated their general health status affected the level of perceived social support and quality of life. In addition, it was found that variables such as economic situation, thinking about changing a profession during the pandemic and getting adequate support in solving problems in the unit where they work affect the quality of life (p<0.05). It was determined that there is a relationship between the perceived social support level of nurses and their quality of life.