Panax ginseng is a Chinese medicinal herb which antioxidant properties would attenuate the intensity of the oxidative stress often involved in the pathogenesis of various diseases. The objective of the present study is to investigate its potential protective effects on CCl(4) toxicity in rats. Four equal groups (n = 10) of adult Wistar albino rats were randomly constituted: group C (healthy controls), group G (rats were orally treated with Panax ginseng (300 mg/kg) for 7 days), group CCl(4) (rats received a single intraperitoneous CCl(4) injection (10 mL/kg)) and group G + CCl(4) (animals were supplemented with Panax ginseng before CCl(4) administration). Mortality and body weight variations were monitored on days 7 and 8 (sacrifice day) while MDA, NO and GSH contents, SOD and GPX activities were measured in liver, heart and kidney and classical histological examination of liver was performed. CCl(4) induced a severe oxidative stress in liver, heart and kidney characterized by strong increases of tissue MDA and NO contents and by marked decreases of GSH concentrations and antioxidant enzyme activities. The high mortality rate and the intense cell degenerescence and fibrosis in liver corroborated the CCl(4) toxicity. By contrast, Panax ginseng pre-treatment elicited protective effects evidenced by decreases of tissue concentrations of oxidative stress markers and the reduction of CCl(4)-induced antioxidant depletion and by histological attenuation of CCl(4)-induced liver injury. These results showed the beneficial antioxidant effects of Panax ginseng on experimentally induced oxidative stress in rats.