Atıf İçin Kopyala
Sülü A., Altay E., Köşger P., Kıztanır H., Uçar B.
European Archives of Medical Research, cilt.39, ss.6-12, 2023 (Hakemli Dergi)
Özet
Objective: It has been reported that the level of vitamin D in obese children is lower and that the low level of vitamin D creates a predisposition to hypertension. In this study, it was aimed to evaluate the relationship between vitamin D level, ambulatory blood pressure parameters, and cardiovascular risk factors in obese children.
Methods: Age, gender, and anthropometric measurements, fasting serum glucose, insulin, transaminase levels, lipid profile, 25(OH) vitamin D levels, 24-hour ambulatory blood pressure monitoring data, electrocardiography and echocardiography data of the patients were
retrospectively obtained from hospital records.
Results: A total of 57 patients between the ages of 8-17 years, 26 females and 31 males, were included in the study. Patients were divided into two groups based on their vitamin D levels below and above 20 ng/mL. A total of 40 patients (70%) were hypertensive, and no correlation was found between blood pressure values and serum vitamin D levels in obese children in the correlation analysis. In the group with a vitamin D level lower than 20 ng/mL, the insulin level and homeostatic model assessment for insulin resistance (HOMA-IR) score were found to be significantly higher than in the other group (p=0.01, p=0.016, respectively). Furthermore, there was a positive correlation between the HOMA-IR score and systolic blood pressure load (r=0.280, p=0.03).
Conclusion: Increased insulin resistance in obese children is associated with high blood pressure values. However, no direct relationship could be found between vitamin D levels and blood pressure profile.
Keywords: Obesity, cardiovascular risk factor, hypertension, vitamin D