The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease
Acta Cardiologica, vol.79, no.2, pp.159-166, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 79 Issue: 2
- Publication Date: 2024
- Doi Number: 10.1080/00015385.2023.2285534
- Journal Name: Acta Cardiologica
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
- Page Numbers: pp.159-166
- Keywords: CAD, LDL subfraction, Sort1 expression, inflammation
- Recep Tayyip Erdoğan University Affiliated: Yes
Abstract
Background: Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research Objectives: The aim of this study was to investigate the association between Sort1 gene expression and lipids, lipoprotein subfractions, and inflammation in CAD. Methods: The study population included 162 subjects with CAD and 49 healthy individuals. The Sort1 gene expression level was determined by qRT-PCR using Human Sortilin TaqMan Gene Expression Assays. Lipoprotein subclasses were analysed by the Lipoprint system. Serum levels of apolipoprotein and CRP were measured by autoanalyzer. Results: Sort1 gene expression and atherogenic subfraction (SdLDL) levels were significantly higher (p < 0.001) while atheroprotective subfraction (LbLDL) was lower in the subjects with CAD (p < 0.050). Also, increased Sort1 gene expression levels were observed in those with higher CRP values. Conclusions: Our findings reveal that the high Sort1 gene expression has a prominent linear relationship with both the atherogenic LDL phenotype and proinflammation, thereby might contribute to the occurrence of CAD.