The role of cysteine cathepsins in cancer progression and drug resistance

Rudzińska M., Parodi A., Soond S. M., Vinarov A. Z., Korolev D. O., Morozov A. O., ...Daha Fazla

International Journal of Molecular Sciences, cilt.20, sa.14, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 20 Sayı: 14
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3390/ijms20143602
  • Dergi Adı: International Journal of Molecular Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Cancer progression, Cysteine cathepsins, Drug resistance
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.