Background: The new lifestyle that emerged in the COVID-19 pandemic and the measures taken to control the epidemic cause individuals to experience intense stress and decrease their sleep quality. Objectives: In this study, it was aimed to determine the relationship between the level of stress and sleep quality that nursing students perceived during the pandemic process. Methods: The study was conducted as a descriptive study with 229 undergraduate students who were ac-tively studying in the nursing department of a state university and accepted to participate in the study. The data of the study were collected online through a structured questionnaire created in Google Forms using the “Descriptive Information Form”, the “Perceived Stress Scale (PSS)” and the “Pittsburg Sleep Quality Index (PUKI)”. Results: The students’ PSS total mean score was 15.36±5.08, and 73.4% of them had poor sleep quality. There is a statistically significant, positive and moderate relationship between the total score of PSS and the total score of PSS. It was found that students who had difficulties in understanding, comprehending and participating in the theoretical and practical lessons in the distance education process, and who thought that the pandemic process increased the stress level and changed their sleeping habits, had higher PSS and PUKI scores. Conclusion: It was determined that as the perceived stress levels of nursing students increased during the pandemic process, their sleep quality decreased. It is thought that stress management practices and elective courses for nursing students should be added to the curriculum during the pandemic process.