Increased circulating soluble CD40 levels in patients with slow coronary flow phenomenon: an observational study


Durakoglugil M. E. , KOCAMAN S. A. , Cetin M. , Kirbas A., CANGA A., Erdogan T. , ...More

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, vol.13, no.1, pp.39-44, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5152/akd.2013.005
  • Title of Journal : ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Page Numbers: pp.39-44
  • Keywords: Slow coronary flow, soluble CD40, C-reactive protein, coronary angiography, regression analysis, HUMAN VASCULAR CELLS, ENDOTHELIAL FUNCTION, OXIDATIVE STRESS, ANGINA-PECTORIS, HUMAN MONOCYTES, ARTERY FLOW, SYNDROME-X, EXPRESSION, LIGAND, ATHEROSCLEROSIS

Abstract

Objective: Slow coronary flow (SCF) is an angiographic finding characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. CD40/CD40 ligand (CD40L) signaling seems closely related to atherosclerosis due to increased inflammation and prothrombotic state. We investigated whether soluble CD40 (sCD40), an indirect marker of CD40/CD40L dyad, is related to SCF.