Increased circulating soluble CD40 levels in patients with slow coronary flow phenomenon: an observational study

Durakoglugil M. E., KOCAMAN S. A., Cetin M., Kirbas A., CANGA A., Erdogan T., ...More

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, vol.13, no.1, pp.39-44, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5152/akd.2013.005
  • Journal Name: ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.39-44
  • Keywords: Slow coronary flow, soluble CD40, C-reactive protein, coronary angiography, regression analysis, HUMAN VASCULAR CELLS, ENDOTHELIAL FUNCTION, OXIDATIVE STRESS, ANGINA-PECTORIS, HUMAN MONOCYTES, ARTERY FLOW, SYNDROME-X, EXPRESSION, LIGAND, ATHEROSCLEROSIS
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective: Slow coronary flow (SCF) is an angiographic finding characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. CD40/CD40 ligand (CD40L) signaling seems closely related to atherosclerosis due to increased inflammation and prothrombotic state. We investigated whether soluble CD40 (sCD40), an indirect marker of CD40/CD40L dyad, is related to SCF.