Impaired left atrial mechanical functions as indicators for increased aortic root diameter in hypertensive and diabetic patients Beeinträchtigte mechanische Funktionen des linken Vorhofs als Indikatoren für einen erhöhten Aortenwurzeldurchmesser bei hypertensiven und diabetischen Patienten

Kalaycıoğlu E., Çetin M., Özyıldız A. G., Kırış T.

Herz, vol.46, pp.272-279, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46
  • Publication Date: 2021
  • Doi Number: 10.1007/s00059-020-04997-x
  • Journal Name: Herz
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.272-279
  • Keywords: Hypertension, Left atrium, Two-dimensional speckle tracking echocardiography, Stroke, Atrial fibrillation, ENDOTHELIAL DYSFUNCTION, DILATATION, POPULATION, ANEURYSM, MARKER, RISK
  • Recep Tayyip Erdoğan University Affiliated: Yes


Objectives: Previous studies have demonstrated that increased aortic root diameter (ARD) is frequently associated with increased cardiovascular (CV) events and is a predictor of stroke. Two-dimensional speckle tracking echocardiography (2D-STE) provides a better evaluation of left atrial (LA) functions. Left atrial mechanical dispersion is a useful predictor of new-onset atrial fibrillation (AF) independent of LA enlargement and dysfunction. We aimed to investigate the relationship between ARD and LA mechanical functions. Methods: The present study included 93 consecutive patients with hypertension and diabetes. The relationships between ARD and LA functions was evaluated. Results: Study population was divided into two groups according to the mean ARD values: group 1 (ARD ≤30.03 mm, n = 53) and group 2 (ARD >30.03 mm, n = 40). In group 2, age, LA max volume (vol), LA pre A vol, LA min vol, LA emptying fraction, LA active ejection fraction (EF), and LA expansion index were significantly higher compared to group 1. S‑LAs and SR-LAs (peak LA strain and strain rate, respectively, during ventricular systole) and S‑LAe and SR-LAe (peak early diastolic LA strain and strain rate, respectively) were significantly lower in group 2 compared to group 1. Age, LA max vol, LA pre A vol, LA min vol, LA emptying fraction, LA active EF, LA expansion index, S‑LAs, S‑LAe, SR-LAs, and SR-LAe were significantly associated with increased ARD. In multivariate logistic regression analysis, age, LA expansion index, and SR-LAe were independent predictors for ARD. Conclusion: Impaired LA mechanical functions determined by speckle tracking methods are related with increased ARD independent of LV diastolic dysfunction.