Meperidine versus valethamate bromide in shortening the duration of active labor


Yilmaz B., Kart C., Kelekci S., Gokturk U., SÜT N., Tarlan N., ...More

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, vol.107, no.2, pp.126-129, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.ijgo.2009.06.021
  • Journal Name: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.126-129
  • Keywords: Acceleration of labor, Duration of labor, Meperidine, Valethamate bromide, RANDOMIZED CONTROLLED-TRIAL, DROTAVERINE HYDROCHLORIDE, OXYTOCIN, ACCELERATION, AUGMENTATION, CORTISOL, DYSTOCIA
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Objective: To compare the efficacy and safety of meperidine hydrochloride and valethamate bromide against placebo in shortening the duration of active labor. Method: We randomly assigned 160 nulliparous women with a singleton pregnancy at term who needed induction of labor to one of 3 treatments: 50 mg of meperidine (n = 53), 16 mg of valethamate bromide (n = 53), or a normal saline solution as placebo (n = 54). All medications were given by slow intravenous infusion. Labor duration was the main outcome measure. Results: The intervals between infusion and complete cervical dilation and between infusion and delivery were significantly reduced (P<0.001 and P<0.01) in the meperidine group (103.0 +/- 64.5 minutes and 119.8 +/- 70.2 minutes), in contrast to the placebo group (173.9 +/- 74.8 minutes and 192.2 +/- 82.8 minutes). However, differences were not significant between the 2 treatment groups (139.6 +/- 63.1 minutes and 160.6 +/- 71.9 minutes), or between the valethamate bromide and the placebo group. Conclusion: Meperidine, but not valethamate bromide, significantly shortened the duration of active labor in nulliparous women with a singleton pregnancy at term. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.