Microwave Assisted Synthesis and Anti-Lipase Activity of Some New Fluorine-Containing Benzimidazoles

Mentese E., Yilmaz F., ULKER S., KAHVECİ B.

DRUG RESEARCH, vol.65, no.1, pp.40-45, 2015 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1055/s-0034-1371890
  • Journal Name: DRUG RESEARCH
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.40-45
  • Keywords: microwave chemistry, fluorine chemistry, anti lipase activity, 2-substituted benzimidazoles, Orlistat, MEDICINAL CHEMISTRY, DERIVATIVES, INHIBITORS, OBESITY, AGENTS
  • Recep Tayyip Erdoğan University Affiliated: Yes


In this study, a new series of fluorine containing benzimidazoles (4a-l) and bisbenzimidazoles (6a-c, 8) were synthesized by the reaction of o-phenylenediamines with iminoester hydrochlorides (3a-l, 7) in methanol under microwave irradiation. The structures of these newly synthesized compounds were identified by IR, H-1-NMR, C-13-NMR, mass spectroscopy and elemental analysis data. The synthesized compounds were screened for their pancreatic lipase activities. Our results indicate that the compounds 6a, 6b and 6c can serve as an anti-lipase agent. The compounds 6b and 6c inhibited pancreatic lipase activity by 84.03% and 97.49% at a concentration of 3 mu g/mL, respectively.