Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis

DILEK, NURSEL; DILEK, AZİZ; TASKIN, Yakup; ERKINURESIN, Taskin; YALCIN, Omer; Saral, YUNUS

doi:10.5114/ada.2016.63882

Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis

DILEK N., DILEK A. R., TASKIN Y., ERKINURESIN T., YALCIN O., Saral Y.

POSTEPY DERMATOLOGII I ALERGOLOGII, cilt.33, sa.6, ss.435-439, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 33 Sayı: 6
Basım Tarihi: 2016
Doi Numarası: 10.5114/ada.2016.63882
Dergi Adı: POSTEPY DERMATOLOGII I ALERGOLOGII
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.435-439
Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Introduction: Histological changes of psoriasis include invasion of neutrophils into the epidermis and formation of Munro abscesses in the epidermis. Neutrophils are the predominant white blood cells in circulation when stimulated; they discharge the abundant myeloperoxidase (MPO) enzyme that uses hydrogen peroxide to oxidize chloride for killing ingested bacteria.