Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis

DILEK N., DILEK A. R., TASKIN Y., ERKINURESIN T., YALCIN O., Saral Y.

POSTEPY DERMATOLOGII I ALERGOLOGII, vol.33, no.6, pp.435-439, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.5114/ada.2016.63882
  • Journal Name: POSTEPY DERMATOLOGII I ALERGOLOGII
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.435-439
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Introduction: Histological changes of psoriasis include invasion of neutrophils into the epidermis and formation of Munro abscesses in the epidermis. Neutrophils are the predominant white blood cells in circulation when stimulated; they discharge the abundant myeloperoxidase (MPO) enzyme that uses hydrogen peroxide to oxidize chloride for killing ingested bacteria.