Synthesis of novel monostyryl and distyryl boron dipyrromethenes bearing 4-((2-hydroxyethyl)(methyl)amino group as cholinesterase and tyrosinase inhibitors


Arslan T., Keles T. , BARUT B., ÖZEL A., BIYIKLIOĞLU Z.

INORGANICA CHIMICA ACTA, cilt.471, ss.121-125, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 471
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.ica.2017.10.020
  • Dergi Adı: INORGANICA CHIMICA ACTA
  • Sayfa Sayıları: ss.121-125

Özet

In this study, the synthesis of novel Monostyryl and Distyryl boron dipyrromethene dyes containing 4-((2-hydroxyethyl)(methyl)amino) group to determine neuroprotective potential has been reported for the first time. They were synthesized starting from BODIPY dye 1. Their inhibitory properties against Acetylcholinesterase/Butyrylcholinesterase (AChE/BuChE) and tyrosinase (Tyr) were evaluated according to Ingkaninan's and Masuda's methods and kinetic analysis of compounds was done using LineweaverBurk and Dixon plots. (C) 2017 Elsevier B.V. All rights reserved.