INCIDENTAL PULMONARY MUCINOUS CYSTADENOMA IN A PATIENT WITH CONCURRENT SQUAMOUS CELL CARCINOMA
CUKUROVA 17th INTERNATIONAL SCIENTIFIC RESEARCHES CONFERENCE, Adana, Türkiye, 10 - 12 Temmuz 2026, ss.1537-1538, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Adana
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.1537-1538
- Recep Tayyip Erdoğan Üniversitesi Adresli: Evet
Özet
Introduction: A mucinous cystadenoma (MC) of the lung is a rare benign tumour that is typically found
on the periphery of the lung. Its slow growth and cystic structure can lead to confusion with other
mucinous lesions on radiological imaging. This presentation discusses a patient with chronic obstructive
pulmonary disease (COPD) who showed tumor growth of MC during follow-up, along with a
simultaneously detected squamous cell carcinoma (SCC), in accordance with the literature. Case presantation: A patient diagnosed with COPD and a history of 50 pack-years of smoking was
found to have a 1-cm-diameter, well-defined nodule in the right lung on a 2018 chest CT scan. A follow-
up CT scan in 2022 revealed that the lesion had grown to 23.7 × 21.5 mm and had developed a
microlobulated margin. Additionally, a second nodule with a spiculated margin, measuring 7.4 x 6.1 mm
and located subpleurally, was identified in the same lobe. In the PET/CT scan, the SUVmax value for
the larger lesion was reported as 2.0, and for the smaller lesion as 9.3. Since biopsies of the smaller
lesion were unsuccessful, the patient underwent a lobectomy.
Macroscopically, two distinct lesions spaced 3.5 cm apart were observed. On the cut surface of the larger
lesion, a thin-walled, multilocular cystic structure filled with dense mucinous content was noted.
Microscopic examination revealed that the lumen of the cystic structures was lined by a well-
differentiated, single-layered, long cylindrical/prismatic epithelium containing apical mucin. No
significant cytological atypia, pleomorphism, or mitotic figures were observed in the epithelial cells. No
evidence of invasion was found in the fibrous stroma forming the cyst wall. The cyst lumens were filled
with acellular dense mucin. Immunohistochemical studies confirmed the benign nature of the
epithelium. The other lesion was identified as a non-keratinizing squamous cell carcinoma with
bronchial invasion and minimal keratinization.
Conclusion: Mucinous cystadenomas of the lung are characterized by low FDG uptake and a slow
growth potential. As in this case, radiological progression may be misleading in the presence of a
concurrent malignancy. In the differential diagnosis, a full-thickness histopathological examination is
critical for ruling out mucinous adenocarcinoma and borderline mucinous tumors. The association of
this rare benign tumor with synchronous lung cancer is significant because it poses diagnostic
challenges.
Keywords: Lung, Mucinous cystadenoma, Squamous cell carcinoma, Synchronous tumor,
Histopathology.