DETERMINATION OF BIOLOGICAL ACTIVITIES AND pKa AT DRUG ACTIVE SUBSTANCE IN SOME BISBENZIMIDAZOLES DERIVATIVES


Islamoglu F., Erdoğan N., Mentese E.

HETEROCYCLIC LETTERS, vol.6, no.3, pp.361-369, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2016
  • Journal Name: HETEROCYCLIC LETTERS
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.361-369
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Bisbenzimidazole derivatives have known different structures as drug active substance were evaluated for their biological activities such as antiviral and anti-tumor activities. In addition, acid dissociation constants (pKa) were determined experimentially with potentiometric titration method and theoretically with SPARC computer programme about state acidity for these five compounds at 25 degrees C.