DETERMINATION OF BIOLOGICAL ACTIVITIES AND pKa AT DRUG ACTIVE SUBSTANCE IN SOME BISBENZIMIDAZOLES DERIVATIVES


Islamoglu F. , Erdoğan N., Mentese E.

HETEROCYCLIC LETTERS, cilt.6, sa.3, ss.361-369, 2016 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Konu: 3
  • Basım Tarihi: 2016
  • Dergi Adı: HETEROCYCLIC LETTERS
  • Sayfa Sayıları: ss.361-369

Özet

Bisbenzimidazole derivatives have known different structures as drug active substance were evaluated for their biological activities such as antiviral and anti-tumor activities. In addition, acid dissociation constants (pKa) were determined experimentially with potentiometric titration method and theoretically with SPARC computer programme about state acidity for these five compounds at 25 degrees C.