Prevalence of non-thyroidal illness syndrome in COPD exacerbation and effect of hypoxaemia and hypercapnia on thyroid functions

Gumus A., Ozyurt S., Ozcelik N., Kara B.

CLINICAL RESPIRATORY JOURNAL, vol.14, no.9, pp.806-812, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.1111/crj.13200
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.806-812
  • Keywords: COPD exacerbation, hypercapnia, hypoxaemia, non-thyroidal illness syndrome, OBSTRUCTIVE PULMONARY-DISEASE, DYSFUNCTION, SEVERITY, MARKERS
  • Recep Tayyip Erdoğan University Affiliated: Yes


Introduction Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease showing acute exacerbations during its course. Comorbidities often accompany. Non-thyroidal illness syndrome (NTIS) occurs because of the functional impairment in the hypothalamic-pituitary-thyroid axis in severe critical cases. The objective of the current study is to determine the prevalence of NTIS among hospitalised patients due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and to reveal the factors affecting thyroid functions.