4th International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 18 - 19 December 2021, pp.33
Cancer remains a common health problem with increasing mortality rates. We aimed to investigate whether there are in vitro anticancer properties of a commercially available polyherbal formulation (PHF) against lung cancer. PHF is an ethanol extract of multiple herbs including Commiphora myrrha, Curcuma zedoaria, Elettaria cardamomum, Olea europaea, Eryngium campestre, Illicium verum, Cinnamomum verum, Myristica fragrans, Crocus sativus. We determined the effects of PHF on viability, colony forming ability, migration and apoptosis of non-small cell lung cancer cells, A549 and human retinal epithelial cells, ARPE-19 as a non-cancerous control. We examined the cytotoxic effect of PHF on cell proliferation in comparison with cisplatin and both showed significant cytotoxic effects on A549 cells. PHF treatment resulted in a relatively mild cytotoxic effect against ARPE-19 cells compared to cisplatin treatment. The inhibition of growth in more than 50% of A549 cells was noted with either 1:25 dilution of PHF or 24 µM of cisplatin treatments. PHF caused a more effective suppression of cell migration compared to cisplatin (P<0.001). Both PHF and cisplatin at IC50 doses effectively inhibited colony formation and induced apoptosis. The mechanisms underlying the anticancer properties of PHF need to be elucidated more comprehensively to confirm its potential.