The Protective Effects of Perindopril Against Acute Kidney Damage Caused by Septic Shock

Kostakoglu U. , Mercantepe T. , Yilmaz H. K. , Tumkaya L. , Batcik S., Pinarbas E. , ...More

INFLAMMATION, vol.44, no.1, pp.148-159, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1007/s10753-020-01316-8
  • Title of Journal : INFLAMMATION
  • Page Numbers: pp.148-159
  • Keywords: inflammation, kidney, oxidative stress, perindopril, rat, sepsis, ACUTE-RENAL-FAILURE, CECAL LIGATION, RAT MODEL, INJURY, SEPSIS, RESVERATROL, DISEASE, STRESS


Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed condition with rising mortality rates. The purpose of this study was to determine whether perindopril (PER) can prevent sepsis-associated AKI with its antioxidant, anti-inflammatory, and anti-apoptotic effects. The control group received an oral saline solution only for 4 days. Cecal ligation and puncture (CLP)-induced sepsis only was applied to the CLP group, while the CLP + PER (2 mg/kg) received CLP-induced sepsis together with 2 mg/kg PER via the oral route for 4 days before induction of sepsis. Finally, all rats were euthanized by anesthesia and sacrificed. TBARS, total SH levels and NF-kappa beta, TNF-alpha, and Caspase-3 expression were then calculated for statistical analysis. TBARS, total SH, NF-k beta/p65, TNF-a, and Caspase-3 levels increased in the CLP group. In contrast, oral administration of PER (2 mg/kg) to septic rats reduced TBARS levels and NF-k beta/p65, TNF-alpha, and Caspase-3 immunopositivity at biochemical analysis. PER treatment appears to be a promising method for preventing sepsis-induced acute kidney injury through its antioxidant anti-inflammation and anti-apoptotic activities.