Rationalization of the Irrational Neuropathologic Basis of Hypothyroidism-Olfaction Disorders Paradox: Experimental Study


Aydin N., Ramazanoglu L., Onen M. R. , Yilmaz I., AYDIN M. D. , Altinkaynak K., ...More

WORLD NEUROSURGERY, vol.107, pp.400-408, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107
  • Publication Date: 2017
  • Doi Number: 10.1016/j.wneu.2017.07.180
  • Title of Journal : WORLD NEUROSURGERY
  • Page Numbers: pp.400-408
  • Keywords: Hypothyroidism, Olfaction disorders, Olfactory bulbectomy, Vagal complex, SUBARACHNOID HEMORRHAGE, HEAD TRAUMA, SKULL BASE, DYSFUNCTION, DISEASE, SMELL, ABNORMALITIES, HORMONE, NERVE, RAT

Abstract

OBJECTIVE: Hypothyroidism is defined as an underactive thyroid gland and one of the reasons for inadequate stimulation of thyroid is dysfunction of the hormone regulating brain centers. Olfaction disorders have been considered as a problem in hypothyroidism. It has been hypothesized that olfaction disorders reduce olfactory stimulation and diminished olfactory stimulus may trigger hypothyroidism. In this study, an examination was made of the thyroid hormone levels, histologic features of thyroid glands, and vagal nerve network degradation in an experimental animal model of olfactory bulbectomy (OBX).