Rapid and efficient synthesis of a new series of 2-aryl-5-fluoro-6(4-phenylpiperazin-1-yl)-1H-benzimidazoles using microwave heating

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Mentese E., Yilmaz F., Islamoglu F., Kahveci B.

JOURNAL OF CHEMICAL RESEARCH, no.4, pp.206-208, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3184/174751915x14268750943001
  • Journal Name: JOURNAL OF CHEMICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.206-208
  • Keywords: benzimidazole, piperazine, microwave, Pd/C catalyst, fluorine atom, BIOLOGICAL-ACTIVITY, RAT HEPATOCYTES, BENZIMIDAZOLES, MEBENDAZOLE, P4501A, POTENT
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

A new series of 2-aryl-5-fluoro-6-(4-phenylpiperazin-1-yl)-1H-benzimidazoles was synthesised from the reaction of 4-fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine and iminoester hydrochlorides. 4-Fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine was prepared from the reduction of 5-fluoro-2-nitro-4-(4-phenylpiperazin-1-yl) aniline by using Pd/C (10%) catalyst and hydrazine hydrate under microwave irradiation. The structures of newly synthesised compounds were identified by H-1 NMR, C-13 NMR, mass spectroscopy and elemental analysis data.