Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives

Balaydin H. T., Senturk M., MENZEK A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.22, sa.3, ss.1352-1357, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.bmcl.2011.12.069
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1352-1357
  • Anahtar Kelimeler: Carbonic anhydrase, Enzyme inhibition, Bromination, Bromophenols, Cyclohexanone with benzyl, Enamine, Esterification, Symphyoketone, IN-VITRO INHIBITION, ERYTHROCYTE GLUTATHIONE-REDUCTASE, ALGA SYMPHYOCLADIA-LATIUSCULA, AROMATIC/HETEROCYCLIC SULFONAMIDES, THERAPEUTIC APPLICATIONS, ODONTHALIA-CORYMBIFERA, PHENOLIC-COMPOUNDS, HUMAN SERUM, ISOZYME-II, PURIFICATION
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl) cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10-17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2-4, 8, and 10-26 was investigated. These compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis. (C) 2011 Elsevier Ltd. All rights reserved.