TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.19, no.2, pp.132-137, 2022 (ESCI)
Article / Article
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
Diospyros lotus, cisplatin, cardiotoxicity, oxidative stress, MOLECULAR-MECHANISMS, ELLAGIC ACID, CHEMOTHERAPY, ANTIOXIDANT, THERAPY, EXTRACT, TISSUE, LIVER, ASSAY
Recep Tayyip Erdoğan University Affiliated:
Objectives: Cisplatin is a powerful chemotherapeutic drug that is used to treatment a wide variety of cancers. Despite clinical data demonstrating the cardiotoxic effect of cisplatin, few studies have been carried to improve the cardiotoxicity of cisplatin. In cisplatin-induced toxicity, oxidative stress plays a critical role. This study determined the effect of Diospyros lotus L. fruit (DL), a powerful antioxidant plant, on heart damage caused by cisplatin through histological examination and oxidative stress parameters.