Protective Role of Diospyros lotus L. in Cisplatin-Induced Cardiotoxicity: Cardiac Damage and Oxidative Stress in Rats


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BAŞAK TÜRKMEN N., Ozek D. A. , TAŞLIDERE A., ÇİFTÇİ O., SARAL Ö. , Gul C. C.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.19, no.2, pp.132-137, 2022 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.4274/tjps.galenos.2021.84555
  • Title of Journal : TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Page Numbers: pp.132-137
  • Keywords: Diospyros lotus, cisplatin, cardiotoxicity, oxidative stress, MOLECULAR-MECHANISMS, ELLAGIC ACID, CHEMOTHERAPY, ANTIOXIDANT, THERAPY, EXTRACT, TISSUE, LIVER, ASSAY

Abstract

Objectives: Cisplatin is a powerful chemotherapeutic drug that is used to treatment a wide variety of cancers. Despite clinical data demonstrating the cardiotoxic effect of cisplatin, few studies have been carried to improve the cardiotoxicity of cisplatin. In cisplatin-induced toxicity, oxidative stress plays a critical role. This study determined the effect of Diospyros lotus L. fruit (DL), a powerful antioxidant plant, on heart damage caused by cisplatin through histological examination and oxidative stress parameters.