Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5-diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach

Erkisa M., Aztopal N., ERTÜRK E., Ulukaya E., Yilmaz V. T., ARI F.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.21, no.14, pp.1850-1860, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 14
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520621666201207090702
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1850-1860
  • Keywords: Epigenetic modulators, valproic acid, Cu(II) complex, breast cancer stem cell, apoptosis, histone deacetylase inhibitor, COPPER COMPLEX, VALPROIC ACID, IN-VITRO, ANTICANCER ACTIVITY, DNA/BSA BINDING, METAL-COMPLEXES, DNA CLEAVAGE, ROS, PATHWAY, DIFFERENTIATION
  • Recep Tayyip Erdoğan University Affiliated: No


Background: Cancer Stem Cells (CSCs) are a subpopulation within the tumor that play a role in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes lead to tumor formation in cancer stem cells and show drug resistance. Epigenetic modulators and /or their combination with different agents have been used in cancer therapy.